Effect of Polyvinyl Pyrolidone on Morphology and Performance of Cellulose Acetate Based Dialysis Membrane


  • H. Waheed School of Chemicals and Materials Engineering, National University of Sciences and Technology, Pakistan
  • A. Hussain School of Chemical and Materials Engineering, National University of Sciences and Technology, Islamabad, Pakistan
Volume: 9 | Issue: 1 | Pages: 3744-3749 | February 2019 | https://doi.org/10.48084/etasr.2491


Polyvinyl pyrolidone (PVP) was added as filler in cellulose acetate (CA) to produce mixed matrix membrane (MMM) for hemodialysis operation. Phase separation induced by diffusion (DIPS) was used for fabrication of mixed matrix CA/PVP flat sheet membranes. The effect of adding PVP was investigated on the morphology and permeation efficiencies of CA membranes. The surface arrangement of polymer and additives in pure and blended membrane was studied by FTIR, contact angle and SEM. Results revealed homogenous and significant mixing of PVP content into pure CA matrix. Performance efficiency of blended membranes was investigated by means of pure water flux (PWF), urea clearance and % rejection of bovine serum albumin (BSA). The observable decrease of contact angle from 83° to 69° in CA/PVP MMM membranes of varying composition effectively revealed enhancement in hydrophilicity of MMM membrane surface. For protein rejection, all CA/PVP membranes rejected>90% of BSA relative to 25% for pure CA membrane. Furthermore, urea clearance behavior for CA/PVP membranes was 62.4% in comparison to 52% for pure CA membrane. The incorporation PVP i.e 1% by weight (Mpvp1) significantly improved the hydrophilicity, PWF, BSA rejection and urea clearance percentages of modified CA membrane for dialysis application.


cellulose acetate, dialysis, membrane, poly vinyl pyrolidone


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S. Farrukh, A. Hussain, N. Iqbal, “Fabrication and characterization of microfiltration blended membranes”, Desalination and Water Treatment, Vol. 52, No. 10-12, pp. 1833-1840, 2013 DOI: https://doi.org/10.1080/19443994.2013.792013

S. Farrukh, F. T. Minhas, A. Hussain, S. Memon, M. I. Bhanger, M. Mujahid, “Preparation, Characterization and applicability of Novel Calix[4]arene based cellulose acetate membrane in gas permeation”, Journal of Applied Polymer Science, Vol. 131, No. 6, 2014 DOI: https://doi.org/10.1002/app.39985

A. Hussain, S. Farrukh, F. T. Minhas, “Two-stage membrane system for post-combustion CO2 capture application”, Energy & Fuels,Vol. 29, No. 10, pp. 6664-6669, 2015 DOI: https://doi.org/10.1021/acs.energyfuels.5b01464

S. S. Hayek, S. Sever, Y. A. Ko, H. Trachtman, M. Awad, S. Wadhwani, M. M. Altintas, C. Wei, A. L. Hotton, A. L. French, L. S. Sperling, S. Lerakis, A. A. Quyyumi, J. Reiser, “Soluble urokinase receptor and chronic kidney disease”, The New England Journal of Medicine, Vol. 373, pp. 1916-1925, 2015 DOI: https://doi.org/10.1056/NEJMoa1506362

C. C. Striemer, T. R. Gaborski, J. L. McGrath, P. M. Fauchet, “Charge- and size-based separation of macromolecules using ultrathin silicon membranes”, Nature, Vol. 445, No. 7129, pp. 749-753, 2007 DOI: https://doi.org/10.1038/nature05532

C. Legallais, G. Catapano, B. V. Harten, U. Baurmeister, “A theoretical model to predict the in vitro performance of hemodiafilters”, Journal of Membrane Science, Vol. 168, No. 1-2, pp. 3-15, 2000 DOI: https://doi.org/10.1016/S0376-7388(99)00297-5

A. Zelman, D. Gisser, G. Strait, V. Bastidas, R. Stephen, C. Kablitz, J. Harrow, B. Deeter, W. J. Kolff, “Pressure control of the ultrafiltration rate during hemodialysis with high-flux dialyzers and the time dependence of membrane transport parameters”, Synthetic Membranes: Volume II, pp. 61-74, American Chemical Society, 1981 DOI: https://doi.org/10.1021/bk-1981-0154.ch006

T. Kanamori, K. Sakai, T. Awaka, M. Fukuda, “An improvement on the method of determining the solute permeability of hollow-fiber dialysis membranes photometrically using optical fibers and comparison of the method with ordinary techniques”, Journal of Membrane Science, Vol. 88, No. 2-3, pp. 159-165, 1994 DOI: https://doi.org/10.1016/0376-7388(94)87003-9

J. Ethkve, P. Dkjardin, M. Boissere, “Influence of pH on the adsorption of lysozyme on a sulfonated membrane with and without poly(ethyleneimine)”, Desalination, Vol. 146, No. 1-3, pp. 111-113, 2002 DOI: https://doi.org/10.1016/S0011-9164(02)00500-3

H. Kataoka, T. Kunitomo, T. Kobayashi, Hemodialysis Method and Membrane, US Patent 4925534, 1990

A. Mochizuki, Y. Seita, T. Nakashima, F. Endo, S. Yamashita, “Polyether-Segmented Nylon Hemodialysis Membrane. V. Evaluation of Blood Compatibility of Polyether-Segmented Nylons”, Journal of Applied Polymer Science,Vol. 67, No. 7, pp. 1253-1257, 1998 DOI: https://doi.org/10.1002/(SICI)1097-4628(19980214)67:7<1253::AID-APP14>3.0.CO;2-2

J. Barzin, J. S. Madaeni, H. Mirzadeh, “Effect of Preparation Conditions on Morphology and Performance of Hemodialysis Membranes Prepared from Polyether Sulphone and Polyvinylpyrrolidone”, Iranian Polymer Journal, Vol. 14, No. 4, pp. 353-360, 2005

A. Higuchia, K. Shiranoa, M. Harashimaa, B. O. Yoona, M. Haraa, M. Hattorib, K. Imamurac, “Chemically modified polysulfone hollow fibers with vinylpyrrolidone having improved blood compatibility”, Biomaterials, Vol. 23, No. 13, pp. 2659-2666, 2002 DOI: https://doi.org/10.1016/S0142-9612(01)00406-9

S. Mei, C. Xiao, X. Hu, “Preparation of Porous PVC Membrane via a Phase Inversion Method from PVC/DMAc/Water/Additives”, Journal of Applied Polymer Science, Vol. 120, No. 1, pp. 557-562, 2011 DOI: https://doi.org/10.1002/app.33219

M. Sivakumar, A. K. Mohana Sundaram, D. Mohan, K. Balu, R. Rangrajan, “Modification of Cellulose Acetate: Its Characterization and Application as an Ultrafiltration Membrane”, Journal of Applied Polymer Science, Vol. 67, No. 11, pp. 1939-1946, 1998 DOI: https://doi.org/10.1002/(SICI)1097-4628(19980314)67:11<1939::AID-APP13>3.0.CO;2-P

M. Irfan, A. Idris, N. M. Yusof, N. F. M. Khairuddin, H. Akhma, “Surface modification and performance enhancement of nano-hybrid f-MWCNT/PVP90/PES hemodialysis membranes”, Journal of Membrane Science, Vol. 467, pp. 73-84, 2014 DOI: https://doi.org/10.1016/j.memsci.2014.05.001

Z. Jia, C. Tian, “Quantitative determination of polyethylene glycol with modified Dragendorff reagent method”, Desalination, Vol. 247, No. 1-3, pp. 423-429, 2009 DOI: https://doi.org/10.1016/j.desal.2008.09.004

J. H. Kim, K. H. Lee, “Effect of PEG additive on membrane formation by phase inversion”, Journal of Membrane Science, Vol. 138, No. 2, pp. 153-163, 1998 DOI: https://doi.org/10.1016/S0376-7388(97)00224-X

A. Idris, L. K. Yet, “The effect of different molecular weight PEG additives on cellulose acetate asymmetric dialysis membrane performance”, Journal of Membrane Science, Vol. 280, No. 1-2, pp. 920-927, 2006 DOI: https://doi.org/10.1016/j.memsci.2006.03.010

C. M. Kee, A. Idris, “Permeability performance of different molecular weight cellulose acetate hemodialysis membrane”, Separation and Purification Technology, Vol. 75, No. 2, pp. 102-113, 2010 DOI: https://doi.org/10.1016/j.seppur.2010.08.013

J. J. Qin, M. H. Oo, Y. M. Cao, L. S. Lee, “Development of a LCST membrane forming system for cellulose acetate ultrafiltration hollow fiber”, Separation and Purification Technolog, Vol. 42, No. 3, pp. 291-295,2005 DOI: https://doi.org/10.1016/j.seppur.2004.07.015

I. C. Kim, K. H. Lee, “Effect of poly(ethylene glycol) 200 on the formation of a polyetherimide asymmetric membrane and its performance in aqueous solvent mixture permeation”, Journal of Membrane Science, Vol. 230, No. 1-2, pp. 183-188, 2004 DOI: https://doi.org/10.1016/j.memsci.2003.11.002

M. M. Castillo-Ortega, A. Najera-Luna, D. E. Rodriguez-Felix, J. E. Encinas, F. Rodriguez-Felix, J. Romero, P. J. Herrera-Franco, “Preparation, characterization and release of amoxicillin from cellulose acetate and poly(vinyl pyrrolidone) coaxial electrospun fibrous membrane”, Materials Science and Engineering: C, Vol. 31, No. 8, pp. 1772-1778, 2011 DOI: https://doi.org/10.1016/j.msec.2011.08.009

Z. Cai , X. Song, Q. Zhang, T. Zhai, “Electrospun Polyindole Nanofibers as a Nano-adsorbent for Heavy Metal Ions Adsorption for Wastewater Treatment”, Fibers and Polymers, Vol. 18, No. 3, pp. 502-513, 2017 DOI: https://doi.org/10.1007/s12221-017-6988-z

S. Ramesh, R. Shanti, E. Morris, “Characterization of conducting cellulose acetate based polymer electrolytes doped with “green” ionic mixture”, Carbohydrate Polymers,Vol. 91, No. 1, pp. 14-21, 2013 DOI: https://doi.org/10.1016/j.carbpol.2012.07.061

J. Bai, Y. Li, C. Zhang, X. Liang, Q. Yang, “Preparing AgBr nanoparticles in poly(vinyl pyrrolidone) (PVP) nanofibers”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 329, No. 3, pp. 165-168, 2008 DOI: https://doi.org/10.1016/j.colsurfa.2008.07.010

M. Gao, L. Sun, Z. Wang, Y. Zhao, “Controlled synthesis of Ag nanoparticles with different morphologies and their antibacterial properties”, Materials Science and Engineering: C, Vol. 33, No. 1, pp. 397-404, 2013 DOI: https://doi.org/10.1016/j.msec.2012.09.005

Y. Iwasaki, H. Yamato, T. N. K. A. Fujieda, U. Uchida, A. H. M. Motojima, M. Fukagawa, “Uremic toxin and bone metabolism”, Journal of bone and mineral metabolism,Vol. 24, No. 2, pp. 172-175, 2006 DOI: https://doi.org/10.1007/s00774-005-0667-7

G. Eknoyan, G. J. Beck, A. K. Cheung, J. T. Daugirdas, T. Greene, J. W. Kusek, M. Allon, J. Bailey, J. A. Dalmez, T. A. Depner, J. T. Dwyer, A. S. Levey, N. W. Levin, E. Milford, D. B. Ornt, M. V. Rocco, G. Schulman, S. J. Schwan, B. P. Teehan, R. Toto, “Effect of dialysis dose and membrane flux in maintenance hemodialysis”, The New England Journal of Medicine, Vol. 347, No. 25, pp. 2010-2018, 2002 DOI: https://doi.org/10.1056/NEJMoa021583


How to Cite

H. Waheed and A. Hussain, “Effect of Polyvinyl Pyrolidone on Morphology and Performance of Cellulose Acetate Based Dialysis Membrane”, Eng. Technol. Appl. Sci. Res., vol. 9, no. 1, pp. 3744–3749, Feb. 2019.


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